Peyronie Disease

Symptoms: pain, deformity, palpable plaque, and erectile dysfunction
ED vs PD: ask, "if your penis was straight with the same quality of rigidity you have now, do you think it would be adequate for penetrative sexual activity?", ED treatments unlikely to cause Peyronie, but more likely to expose patients who would otherwise not notice
Assess ED risk factors: DM, HTN, HLD, smoking
Resolution:50% see worsening curvature 12-18 months after presentation, 13% or less see some improvement
Risk factors: prior trauma, sexual microtrauma, DM, low T, smoking, alcohol, ED, associated with depression, anxiety, and other psychosocial issues, some association with Dupuytren disease (hand/foot contractures)
Questionnaire: assess severity with the PDQ (PDF here)

Ask to bring picture from home of erection from above and from the side
Exam: examine penis on stretch and palpate for plaques, can use goniometer to accurately measure curvature severity
Stretched penile length: pubis to corona dorsally
Further testing: no benefit to US or lab evaluation
Intracavernosal injection: recommended to perform in-office prior to any invasive therapies
congenital penile curvature (CPC): important to differentiate, shows smooth curvature on exam without plaques

Peyronie treatment algorithm, from Campbell's

Peyronie consent tips, from Campbell's

Xiaflex (collagenase Clostridium histolyticum): proven to improve curvature, side effects include bruising (80%), swelling (55%), pain (45%), hematoma (3.7%), penile fracture (0.4-1.5%)
Xiaflex technique: inject two dose (1-3d apart), then in-office modeling (grasp 1cm proximal and distal, bend opposite curvature x30s x3), perform up to 4 cycles, 6wk between cycles, stop once curvature < 15deg
IMPRESS trial: 8 injections 0.58mg CCH with modeling, 34% average improvement
Collagenase penile fractures: manage conservatively, likely to heal, hard to repair surgically due to poor tissue quality

Intralesional verapamil: unclear dosing and frequency, some proven treatment benefit, side effects include bruising, dizziness, nausea, pain
Intralesional IFN-a: can offer (per guidelines), side ffects include sinusitis, flu symptoms, penile swelling
Other options:ral agents, topical agents, XRT, and shock wave therapy have not been shown to provide a treatment benefit
Traction: small improvement in curvature and length, 85% satisfaction, need to wear for 3+hr daily
Acute setting: manage pain with NSAIDs

Indications: inability to have satisfactory intercourse, pain to self or partner, or distress due to appearance
Timing: wait until at least 3-6mo after initial symptoms and pain has resolved
Consent: penile shortening, decreased sensation, decreased rigidity, persistent curvature, appearance
Postop care: avoid intercourse for 4-6 weeks, can perform massage/stretching (unclear benefits), consider traction if tolerable

Indications: < 60deg and adequate erection/length, not adequate for severe curvatures or hourglass deformities

Success: fixes curvature in > 80%, > 70% satisfaction

Nesbit: elliptical portion of tunica excised opposite plaque and closed transversely

Yachia corporoplasty: longitudinal incision opposite plaque, closed transversely

Dot plication: imbrication of tunica opposite plaque, no tunical incisions

Indications: better choice for severe curvature or hourglass deformity but more likely to result in inadequate erections
Options: excision has higher rate of postop ED, incision is preferred
Graft choices: can use autologous (penile vein, saphenous vein, fascia lata, rectus fascia), allografts (human pericardium), xenografts (bovine pericardium), or synthetic (gortex, dacron)
Success: fixes curvature in > 80%, > 70% satisfaction

Indications: if ED in presence of PD, treat ED w/ IPP and intraop grafting/plication
Maximal modeling: maximally inflate cylinders, bend penis in direction opposite plaque x90s, can inflate more, may feel plaque "crack"
Side effects: biggest patient concern is postoperative loss of length, urethral injury occurs 2-3% during modeling

AUA Core Curriculum
Nehra, Ajay, et al. "Peyronie’s disease: AUA guideline." The Journal of urology 194.3 (2015): 745-753.
Seftel, A. and H. Yang. "Diagnosis and Management of Peyronie's Disease." Campbell-Walsh Urology 12 (2020).
Wieder JA: Pocket Guide to Urology. Sixth Edition. J.Wieder Medical: Oakland, CA, 2021.

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